Migration Testing Conditions That Do Not Match Your Filling Line
Matching migration simulant and thermal parameters to exact filling line mechanics prevents compliance invalidation during customs and market audit checks.
Chromatographic Verification
Molecular Separation
High performance liquid chromatography provides a method for identifying the chemical composition of substances through the differential partitioning of components between a stationary phase and a mobile phase. Chromatographic verification occurs when analytical data confirms the identity or purity of a chemical constituent against a established reference standard. This process prevents the inclusion of unauthorized plasticizers or contaminants in polymer films and barrier coatings.
Analytical Precision
Quantitative results derive from the integration of peaks recorded on a detector signal plot during the passage of the mobile phase. Chromatographic verification determines the concentration of additives by comparing observed retention times against known elution profiles. Differences between the recorded peak area and the calibration curve reveal variations in the batch composition.
Deviations beyond defined tolerances force the rejection of raw material lots before they enter the manufacturing flow.
Operational Boundary
Regulatory standards for food contact packaging define the acceptable migration limits for specific chemical species that chromatography identifies. Chromatographic verification confirms that the concentration of these species remains below mandated thresholds. Suppliers demonstrate compliance with migration safety requirements through these objective data sets.
Test results provide the necessary evidence to support the validity of safety claims for substrates used in food or pharmaceutical storage.